hoanglabregen.com

Publications

   * Co-first author, # Corresponding author

2024

  1. A. Upreti, T. Hoang, M. Li, J. A. Tangeman, D. S. Dierker, B. D. Wagner, P. A. Tsonis, C. Liang, S. A. Lachke, M. L. Robinson, miR-26 deficiency causes alterations in lens transcriptome and results in adult-onset cataract.Investigative Ophthalmology & Visual Science (IOVS) (2024).

2023

  1. N.Le, T.D.Vu, I.Palazzo,  R. Pulya, Y. Kim,  S. Blackshaw#, T. Hoang#. Robust reprogramming of glia into neurons by inhibition of Notch signaling and NFI factors in adult mammalian retina. BioRxiv 2023
  2. T. Hoang*#, D. W. Kim*#, H. Appel, M. Ozawa, S. Zheng, J. Kim, S. Blackshaw. Ptbp1 deletion does not induce astrocyte-to-neuron conversion  Nature 618, E1–E7 (2023).
  3. P. Lyu*, M. Iribarne*, D. Serjanov*, Y. Zhai*, T. Hoang*, L. J. Campbell, P. Boyd, I. Palazzo, M. Nagashima, N. J. Silva, P. F. Hitchcock, J. Qian, D. R. Hyde, S. Blackshaw, Common and divergent gene regulatory networks control injury-induced and developmental neurogenesis in zebrafish retina. Nat. Commun. 14, 1–21 (2023).
  4. K. Emmerich, J. Hageter, T. Hoang, P. Lyu, A. V. Sharrock, A. Ceisel, J. Thierer, Z. Chunawala, S. Nimmagadda, I. Palazzo, F. Matthews, L. Zhang, D. T. White, C. Rodriquez, G. Graziano, P. Marcos, A. May, T. Mulligan, B. Reibman, M. T. Saxena, D. F. Ackerley, J. Qian, S. Blackshaw, E. Horstick, J. S. Mumm, Molecular regulation of retinal regeneration is context specific. bioRxiv (2023), p. 2023.11.20.567904.

2022

  1. T. Hoang*#, D. W. Kim*#, H. Appel, N. A. Pannullo, P. Leavey, M. Ozawa, S. Zheng, M. Yu, N. S. Peachey, S. Blackshaw, Genetic loss of function of Ptbp1 does not induce glia-to-neuron conversion in retina: Cell Reports, 39(11), 110849. (2022).
  2. N. Le, H. Appel, N. Pannullo, T. Hoang, S. Blackshaw. Ectopic insert-dependent neuronal expression of GFAP promoter-driven AAV constructs in adult mouse retina.Front. Cell Dev. Biol. 2022.
  3. E. D. Thomas, A. E. Timms, S. Giles, S. Harkins-Perry, P. Lyu, T. Hoang, J. Qian, V. E. Jackson, M. Bahlo, S. Blackshaw, M. Friedlander, K. Eade, T. J. Cherry, Cell-specific cis-regulatory elements and mechanisms of non-coding genetic disease in human retina and retinal organoids. Dev. Cell (2022), doi:10.1016/j.devcel.2022.02.018.
  4. S. H. Shah, L. M. Schiapparelli, Y. Ma, S. Yokota, M. Atkins, X. Xia, E. G. Cameron, T. Hoang, S. Saturday, C. B. Sun, C. Knasel, S. Blackshaw, J. R. Yates Iii, H. T. Cline, J. L. Goldberg, Quantitative transportomics identifies Kif5a as a major regulator of neurodegeneration. Elife. 11 (2022), doi:10.7554/eLife.68148.
  5. E. H. Choi , S. Suh, A. Foik, H. Leinonen, G. A. Newby, S.  Banskota , T. Hoang , S. Du , X. D. Gao , Z. Dong , A. Raguram ,S. Kohli, S. Blackshaw, D. C. Lyon , D. R Liu, K. Palczewski. In vivo base editing rescues the function and survival of cone photoreceptors in a mouse model of early-onset inherited retinal degeneration. Nature communications (2022).
  6. I. Palazzo, L. J. Todd, T. Hoang, T. A. Reh, S. Blackshaw, A. J. Fischer, NFkB-signaling promotes glial reactivity and suppresses Müller glia-mediated neuron regeneration in the mammalian retina. GLIA 2022, doi:10.1101/2021.10.05.463152.
  7. W. A. Campbell, A. Tangeman, H. M. El-Hodiri, E. C. Hawthorn, M. Hathoot, S. Blum, T. Hoang, S. Blackshaw, A. J. Fischer, Fatty acid-binding proteins and fatty acid synthase influence glial reactivity and promote the formation of Müller glia-derived progenitor cells in the chick retina. Development. 149 (2022), doi:10.1242/dev.200127.
  8. D. Lewandowski, A. T. Foik, R. Smidak, E. H. Choi, J. Zhang, T. Hoang, A. Tworak, S. Suh, H. Leinonen, Z. Dong, A. F. Pinto, E. Tom, J. Luu, J. Lee, X. Ma, E. Bieberich, S. Blackshaw, A. Saghatelian, D. C. Lyon, D. Skowronska-Krawczyk, M. Tabaka, K. Palczewski, Inhibition of ceramide accumulation in AdipoR1-/- mice increases photoreceptor survival and improves vision. JCI Insight. 7 (2022), doi:10.1172/jci.insight.156301.

2021

  1. P. Lyu*, T. Hoang*, C. P. Santiago, E. D. Thomas, A. E. Timms, H. Appel, M. Gimmen, N. Le, L. Jiang, D. W. Kim, S. Chen, D. Espinoza, A. E. Telger, K. Weir, B. S. Clark, T. J. Cherry, J. Qian, S. Blackshaw, Gene regulatory networks controlling temporal patterning, neurogenesis, and cell fate specification in the mammalian retina.:Cell Reports (2021).
  2. W. A. Campbell, S. Blum, A. Reske, T. Hoang, S. Blackshaw, A. J. Fischer, Cannabinoid signaling promotes the de-differentiation and proliferation of Müller glia-derived progenitor cells. Glia. 69, 2503–2521 (2021).
  3. D. W. Kim, K. Taneja, T. Hoang, C. P. Santiago, T. J. McCulley, S. L. Merbs, N. R. Mahoney, S. Blackshaw, F. Rajaii, Transcriptomic Profiling of Control and Thyroid-Associated Orbitopathy (TAO) Orbital Fat and TAO Orbital Fibroblasts Undergoing Adipogenesis. Invest. Ophthalmol. Vis. Sci. 62, 24 (2021).
  4. W. A. Campbell, A. Fritsch-Kelleher, I. Palazzo, T. Hoang, S. Blackshaw, A. J. Fischer, Midkine is neuroprotective and influences glial reactivity and the formation of Müller glia-derived progenitor cells in chick and mouse retinas. Glia. 69, 1515–1539 (2021).
  5. S. Yoo, J. Kim, P. Lyu, T. Hoang, A. Ma, V. Trinh, W. Dai, L. Jiang, P. Leavey, L. Duncan, J.-K. Won, S.-H. Park, J. Qian, S. P. Brown, S. Blackshaw, Control of neurogenic competence in mammalian hypothalamic tanycytes. Sci Adv. 7 (2021), doi:10.1126/sciadv.abg3777.

2020

  1. T. Hoang*, J. Wang*, P. Boyd, F. Wang, C. Santiago, L. Jiang, S. Yoo, M. Lahne, L. J. Todd, M. Jia, C. Saez, C. Keuthan, I. Palazzo, N. Squires, W. A. Campbell, F. Rajaii, T. Parayil, V. Trinh, D. W. Kim, G. Wang, L. J. Campbell, J. Ash, A. J. Fischer, D. R. Hyde, J. Qian, S. Blackshaw, Gene regulatory networks controlling vertebrate retinal regeneration. Science. 370 (2020), doi:10.1126/science.abb8598.
  2. J. Luu, L. Kallestad, T. Hoang, D. Lewandowski, Z. Dong, S. Blackshaw, K. Palczewski, Epigenetic hallmarks of age-related macular degeneration are recapitulated in a photosensitive mouse model. Human Molecular Genetics. 29 (2020), pp. 2611–2624.
  3. Y. Lu, F. Shiau, W. Yi, S. Lu, Q. Wu, J. D. Pearson, A. Kallman, S. Zhong, T. Hoang, Z. Zuo, F. Zhao, M. Zhang, N. Tsai, Y. Zhuo, S. He, J. Zhang, G. L. Stein-O’Brien, T. D. Sherman, X. Duan, E. J. Fertig, L. A. Goff, D. J. Zack, J. T. Handa, T. Xue, R. Bremner, S. Blackshaw, X. Wang, B. S. Clark, Single-Cell Analysis of Human Retina Identifies Evolutionarily Conserved and Species-Specific Mechanisms Controlling Development. Dev. Cell. 53, 473–491.e9 (2020).
  4. I. Palazzo, K. Deistler, T. Hoang, S. Blackshaw, A. J. Fischer, NF-κB signaling regulates the formation of proliferating Müller glia-derived progenitor cells in the avian retina. Development. 147 (2020), doi:10.1242/dev.183418.

2019

  1. J. Zhang, E. H. Choi, A. Tworak, D. Salom, H. Leinonen, C. L. Sander, T. Hoang, J. T. Handa, S. Blackshaw, G. Palczewska, P. D. Kiser, K. Palczewski, Photic generation of 11-cis-retinal in bovine retinal pigment epithelium. Journal of Biological Chemistry. 294 (2019), pp. 19137–19154.
  2. B. S. Clark, G. L. Stein-O’Brien, F. Shiau, G. H. Cannon, E. Davis-Marcisak, T. Sherman, C. P. Santiago, T. Hoang, F. Rajaii, R. E. James-Esposito, R. M. Gronostajski, E. J. Fertig, L. A. Goff, S. Blackshaw, Single-Cell RNA-Seq Analysis of Retinal Development Identifies NFI Factors as Regulating Mitotic Exit and Late-Born Cell Specification. Neuron. 102, 1111–1126.e5 (2019).
  3. W. A. Campbell 4th, A. Deshmukh, S. Blum, L. Todd, N. Mendonca, J. Weist, J. Zent, T. Hoang, S. Blackshaw, J. Leight, A. J. Fischer, Matrix-metalloproteinase expression and gelatinase activity in the avian retina and their influence on Müller glia proliferation. Exp. Neurol. 320, 112984 (2019).
  4. L. Todd, I. Palazzo, L. Suarez, X. Liu, L. Volkov, T. Hoang, W. A. Campbell, S. Blackshaw, N. Quan, A. J. Fischer, Reactive microglia and IL1β/IL-1R1-signaling mediate neuroprotection in excitotoxin-damaged mouse retina. Journal of Neuroinflammation. 16 (2019), , doi:10.1186/s12974-019-1505-5.
  5. S. Yoo, D. Cha, D. W. Kim, T. Hoang, S. Blackshaw, Tanycyte-Independent Control of Hypothalamic Leptin Signaling. Front. Neurosci. 13, 240 (2019).
  6. T. Getter, S. Suh, T. Hoang, J. T. Handa, Z. Dong, X. Ma, Y. Chen, S. Blackshaw, K. Palczewski, The selective estrogen receptor modulator raloxifene mitigates the effect of all–retinal toxicity in photoreceptor degeneration. J. Biol. Chem. 294, 9461–9475 (2019).
  7. P. D. Kiser, A. V. Kolesnikov, J. Z. Kiser, Z. Dong, B. Chaurasia, L. Wang, S. A. Summers, T. Hoang, S. Blackshaw, N. S. Peachey, V. J. Kefalov, A. K. Palczewski, Conditional deletion of Des1 in the mouse retina does not impair the visual cycle in cones. The FASEB Journal. 33 (2019), pp. 5782–5792.
  8. P. T. Lam, S. L. Padula, T. Hoang, J. E. Poth, L. Liu, C. Liang, A. S. LeFever, L. M. Wallace, R. Ashery-Padan, P. K. Riggs, J. E. Shields, O. Shaham, S. Rowan, N. L. Brown, T. Glaser, M. L. Robinson, Considerations for the use of Cre recombinase for conditional gene deletion in the mouse lens. Hum. Genomics. 13, 10 (2019).
  9. S. L. Padula, D. Anand, T. Hoang, B. R. Chaffee, L. Liu, C. Liang, S. A. Lachke, M. L. Robinson, High-throughput transcriptome analysis reveals that the loss of Pten activates a novel NKX6-1/RASGRP1 regulatory module to rescue microphthalmia caused by Fgfr2-deficient lenses. Hum. Genet. 138, 1391–1407 (2019).
  10. J. Wang, C. Zibetti, P. Shang, S. R. Sripathi, P. Zhang, M. Cano, T. Hoang, S. Xia, H. Ji, S. L. Merbs, D. J. Zack, J. T. Handa, D. Sinha, S. Blackshaw, J. Qian, ATAC-Seq analysis reveals a widespread decrease of chromatin accessibility in age-related macular degeneration. Nat. Commun. 9, 1364 (2018).

Before 2017

  1. T. Hoang*, E. R. Horowitz*, B. R. Chaffee, P. Qi, R. E. Flake, D. G. Bruney, B. J. Rasor, S. E. Rosalez, B. D. Wagner, M. L. Robinson, Lens development requires DNMT1 but takes place normally in the absence of both DNMT3A and DNMT3B activity. Epigenetics. 12, 27–40 (2017).
  2. B. R. Chaffee*, T. Hoang*, M. R. Leonard, D. G. Bruney, B. D. Wagner, J. R. Dowd, G. Leone, M. C. Ostrowski, M. L. Robinson, FGFR and PTEN signaling interact during lens development to regulate cell survival. Developmental Biology. 410 (2016), pp. 150–163.
  3. P. K. R. Kumar*, T. Hoang*, M. L. Robinson, P. A. Tsonis, C. Liang, CADBURE: A generic tool to evaluate the performance of spliced aligners on RNA-Seq data. Scientific Reports. 5 (2015), , doi:10.1038/srep13443.
  4. T. Hoang*, P. K. R. Kumar*, S. Sutharzan, P. A. Tsonis, C. Liang, M. L. Robinson, Comparative transcriptome analysis of epithelial and fiber cells in newborn mouse lenses with RNA sequencing. Mol. Vis. 20, 1491–1517 (2014).